Liver Disease Information
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American Liver Foundation
39 Broadway, Suite 2700
New York, New York 10006
Charles M. Rice, Ph.D., Maurice R. and Corinne P. Greenberg Professor in Virology and head, Laboratory of Virology and Infectious Disease; scientific director, Center for the Study of Hepatitis C, The Rockefeller University
For the past 20-plus years since the discovery of hepatitis C virus, systems for unraveling the virus lifecycle and controlling HCV have evolved slowly. Recently, Dr. Rice and colleagues have developed primary cell culture systems and small animal models that finally allow virus-host interactions to be studied in vitro and in vivo. This work is revealing a complex interplay between the virus and host innate immune responses that may limit virus spread, on the one hand, yet contribute to HCV's remarkable ability to persist.
Dr. Rice received his Ph.D. in biochemistry in 1981 from the California Institute of Technology, where he was also a postdoctoral research fellow from 1981 to 1985. Before he joined Rockefeller in 2000, he spent 14 years on the faculty of the Washington University School of Medicine. Dr. Rice is executive and scientific director of the Center for the Study of Hepatitis C, an interdisciplinary center established jointly by The Rockefeller University, New York-Presbyterian Hospital and Weill Cornell Medical College. He holds numerous U.S. and Global patents related to hepatitis C virus molecular biology, has published almost three hundred original research publications in peer-reviewed journals as well as numerous review articles and book chapters. Dr. Rice was elected to the National Academy of Sciences in 2005 in recognition of his accomplishments.
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